# TKTD RNA Pulse model

The toxicokinetic-toxicodynamic TKTD-RNA Pulse model is a description of the toxic response in zebrafish embryos. It models the toxicant uptake, RNA transcription, toxicant metabolization and survival.

[Schunck et al. 2024, Integrating Time-Resolved nrf2 Gene-Expression Data into a Full GUTS Model as a Proxy for Toxicodynamic Damage in Zebrafish Embryo, ES&T](https://pubs.acs.org/doi/10.1021/acs.est.4c06267)

**Examples**

```{toctree}
:maxdepth: 1

tktd_rna_3_6c_substance_specific.md
tktd_rna_3_6c_substance_independent.md
```