TKTD RNA Pulse model

The toxicokinetic-toxicodynamic TKTD-RNA Pulse model is a description of the toxic response in zebrafish embryos. It models the toxicant uptake, RNA transcription, toxicant metabolization and survival.

Schunck et al. 2024, Integrating Time-Resolved nrf2 Gene-Expression Data into a Full GUTS Model as a Proxy for Toxicodynamic Damage in Zebrafish Embryo, ES&T

Examples

• GUTS-RNA-pulse substance specific
• RNA pulse 5 substance independent